1. Product Name: Quercetin
English name: Quercetin
Chinese alias: quercetin, quercetin, quercetin, quercetin, 2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-4H-chromene-4-one
Molecular weight: 302.236
Molecular formula: C15H10O7
CAS Number: 117-39-5
Detection method: high performance liquid chromatography HPLC≥90%
Appearance: Yellow needle-like crystalline powder; slightly soluble in water, easily soluble in alkaline aqueous solution
Source: This product is derived from Sophora japonica.
Quercetin is widely present in the stem bark, flowers, leaves, buds, seeds, and fruits of many plants, mostly in the form of glycosides, such as rutin, quercetin, hypericin, etc., and quercetin can be obtained by acid hydrolysis cortex. Among them, the content is higher in the stems and leaves of buckwheat, sea buckthorn, hawthorn and onion. contain this ingredient.
The preparation methods of quercetin include extraction and separation, acid hydrolysis, and enzymatic transformation, among which enzymatic transformation is the most practical.
Natural extraction and separation
Since the content of quercetin in plants is only a few thousandths to a few thousandths, and the extraction and separation is difficult and the cost is high, it is not practical to extract quercetin directly from plants. However, when analyzing, identifying flavonoids or preparing analytically pure samples, quercetin extraction and separation techniques are used.
The rutin (rutin) of quercetin is widely distributed in nature and has a high content. For example, the content in sophora japonica is as high as 20%. It is feasible to extract rutin from Sophora japonica, and then generate quercetin after acid hydrolysis.
The extraction methods of rutin mainly include alkali extraction and acid precipitation, organic solvent extraction and dipping, among which alkali extraction and acid precipitation is the most practical. Select 0.05% NaOH solution to boil for 20min, filter while hot, and extract 4 times with the same method to obtain an alkaline aqueous solution of rutin, add acid to make it precipitate, filter and add acid to make it hydrolyzed to obtain water-insoluble quercetin, filter , washed with water and dried to obtain quercetin solid.
Enzymatic hydrolysis of rutin is used to prepare a large amount of quercetin monomers with less content in plants. The operation is simple and safe, the whole process is economical and applicable, the yield is large, suitable for industrial production, and the product purity is more than 90%, which can meet the needs of food and clinical applications . Therefore, enzymatic transformation is undoubtedly a promising preparation method.
1.Quercetin inhibits platelet aggregation, as well as decreasing capillary permeability, making the blood thinner and improving circulation.
2.Quercetin has anti-inflammatory activity.
3.Quercetininhibits aldose reductase activity. Aldose reductase is an enzyme normally present in the eye and elsewhere in the body.It helps change glucose into a sugar alcohol called sorbitol.
4.Quercetin also strengthens the capillaries, and, therefore, can reduce the symptoms of haemophilia. It also may help to prevent acommon unpleasant-looking venous edema of the legs. Rutin, as ferulic acid, can reduce the cytotoxicity of oxidized LDL cholesterol and lower the risk of heart disease.
5. There is also some evidence that Rutin can be used to treat hemorrhoids, varicosis, and microangiopathy.
6. Quercetinis also an antioxidant, along with quercetin, acacetin, morin, hispidulin, hesperidin, and naringin; it was found to be the strongest.
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